MAGI3

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.^[5][6][7]

MAGI3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SOE
Identifiers
Aliases	MAGI3, MAGI-3, dJ730K3.2, membrane associated guanylate kinase, WW and PDZ domain containing 3
External IDs	OMIM: 615943; MGI: 1923484; HomoloGene: 26431; GeneCards: MAGI3; OMA:MAGI3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 113,390,515 bp[1] End 113,685,923 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 45.52 cM Start 103,920,575 bp[2] End 104,127,690 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung nasal epithelium mucosa of ileum jejunal mucosa mucosa of colon palpebral conjunctiva mucosa of sigmoid colon corpus epididymis pars compacta mucosa of pharynx Top expressed in atrioventricular valve globus pallidus habenula superior colliculus dorsal tegmental nucleus left lung lobe medial vestibular nucleus ventral tegmental area ciliary body piriform cortex More reference expression data BioGPS n/a
Gene ontology Molecular function molecular adaptor activity nucleotide binding guanylate kinase activity protein binding ATP binding Cellular component plasma membrane membrane nucleus cell-cell junction bicellular tight junction cell junction cytoplasm Biological process regulation of JNK cascade intracellular signal transduction viral process signal transduction apoptotic process GDP metabolic process GMP metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 260425 99470 Ensembl ENSG00000081026 ENSMUSG00000052539 UniProt Q5TCQ9 Q9EQJ9 RefSeq (mRNA) NM_001142782 NM_020965 NM_152900 NM_001159354 NM_133853 RefSeq (protein) NP_001136254 NP_690864 NP_690864.2 NP_001152826 NP_598614 Location (UCSC) Chr 1: 113.39 – 113.69 Mb Chr 3: 103.92 – 104.13 Mb PubMed search [3] [4]
Wikidata
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Interactions

MAGI3 has been shown to interact with PTPRB^[8] and PTEN.^[6]