MAM domain

MAM domain is an evolutionary conserved protein domain. It is an extracellular domain found in many receptors.

MAM domain
Identifiers
Symbol	MAM
Pfam	PF00629
InterPro	IPR000998
PROSITE	PDOC00604
CDD	cd06263
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2c9aA:27-184

A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins.^[1] These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein);^[2] A5 antigen (a developmentally-regulated cell surface protein; Xenopus nrp1; P28824);^[3] and receptor-like tyrosine protein phosphatase.^[4] The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.

Human proteins containing this domain

ALK; EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2; MEP1A; MEP1B; NPNT; NRP1; NRP2; PRSS7; PTPRK; PTPRM; PTPRO; PTPRT; PTPRU; ZAN