MAP1LC3A

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.^[5][6][7] Two transcript variants encoding different isoforms have been found for this gene.

MAP1LC3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ECI, 3WAL, 3WAN, 4ZDV
Identifiers
Aliases	MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, microtubule associated protein 1 light chain 3 alpha
External IDs	OMIM: 601242; MGI: 1915661; HomoloGene: 12021; GeneCards: MAP1LC3A; OMA:MAP1LC3A - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,546,854 bp[1] End 34,560,345 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,118,217 bp[2] End 155,119,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex prefrontal cortex hypothalamus C1 segment amygdala anterior pituitary Top expressed in lip muscle of thigh right ventricle dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex seminiferous tubule dorsomedial hypothalamic nucleus digastric muscle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylethanolamine binding protein binding phospholipid binding ubiquitin protein ligase binding microtubule binding Cellular component cytoplasm organelle membrane cytosol late endosome membrane autophagosome microtubule cytoskeleton cytoplasmic vesicle endomembrane system autolysosome autophagosome membrane synapse Biological process autophagy autophagy of mitochondrion autophagosome assembly response to iron(II) ion response to lead ion response to nutrient levels cellular response to amino acid starvation response to morphine cellular response to hydrogen peroxide cellular response to copper ion cellular response to nitrogen starvation cellular response to starvation macroautophagy autophagosome maturation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84557 66734 Ensembl ENSG00000101460 ENSMUSG00000027602 UniProt Q9H492 Q91VR7 RefSeq (mRNA) NM_032514 NM_181509 NM_025735 RefSeq (protein) NP_115903 NP_852610 NP_080011 Location (UCSC) Chr 20: 34.55 – 34.56 Mb Chr 2: 155.12 – 155.12 Mb PubMed search [3] [4]
Wikidata
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Function

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.^[7]

MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy.^[8]

Regulation

MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A,^[9] which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.^[10]