MAP2K5

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.^[5][6]

MAP2K5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NPT, 2O2V, 4IC7
Identifiers
Aliases	MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, mitogen-activated protein kinase kinase 5
External IDs	OMIM: 602520; MGI: 1346345; HomoloGene: 115933; GeneCards: MAP2K5; OMA:MAP2K5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 67,542,703 bp[1] End 67,807,117 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B- C Start 63,071,050 bp[2] End 63,285,184 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis parotid gland gonad right frontal lobe Achilles tendon gastrocnemius muscle ventricular zone Brodmann area 9 prefrontal cortex Top expressed in internal carotid artery external carotid artery motor neuron Rostral migratory stream spermatocyte CA3 field right kidney seminiferous tubule primitive streak left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding kinase activity protein binding protein tyrosine kinase activity ATP binding protein serine/threonine kinase activity MAP kinase kinase activity Cellular component cytoplasm cytosol spindle nucleus intracellular anatomical structure Biological process negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of cysteine-type endopeptidase activity involved in apoptotic process phosphorylation positive regulation of epithelial cell proliferation cellular response to laminar fluid shear stress cellular response to growth factor stimulus negative regulation of transcription by RNA polymerase II negative regulation of response to cytokine stimulus MAPK cascade ERK5 cascade negative regulation of cell migration involved in sprouting angiogenesis protein phosphorylation heart development positive regulation of cell growth peptidyl-tyrosine phosphorylation negative regulation of heterotypic cell-cell adhesion negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of NF-kappaB transcription factor activity signal transduction positive regulation of transcription by RNA polymerase II regulation of mitotic cell cycle stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5607 23938 Ensembl ENSG00000137764 ENSMUSG00000058444 UniProt Q13163 Q9WVS7 RefSeq (mRNA) NM_001206804 NM_002757 NM_145160 NM_145161 NM_145162 NM_011840 NM_001364492 NM_001364493 NM_001364494 RefSeq (protein) NP_001193733 NP_002748 NP_660143 NP_035970 NP_001351421 NP_001351422 NP_001351423 Location (UCSC) Chr 15: 67.54 – 67.81 Mb Chr 9: 63.07 – 63.29 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.^[6]

Upstream

This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).

Downstream

This kinase specifically interacts with and activates MAPK7/ERK5.

Interactions

MAP2K5 has been shown to interact with MAPK7,^[5] MAP3K2,^[7] Protein kinase Mζ^[8] and MAP3K3.^[7][9]