MAP3K2

Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.^[5][6][7]

MAP3K2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CU1, 2NPT, 5EX0, 5HQ8
Identifiers
Aliases	MAP3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
External IDs	OMIM: 609487; MGI: 1346873; HomoloGene: 74576; GeneCards: MAP3K2; OMA:MAP3K2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,298,668 bp[1] End 127,388,465 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 32,296,142 bp[2] End 32,369,804 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of paranasal sinus trabecular bone tail of epididymis caput epididymis corpus epididymis epithelium of nasopharynx nipple bronchial epithelial cell pylorus Top expressed in Rostral migratory stream renal corpuscle medullary collecting duct ciliary body iris substantia nigra Paneth cell cumulus cell fossa conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding protein kinase binding kinase activity ATP binding protein serine/threonine kinase activity transferase activity MAP kinase kinase kinase activity metal ion binding protein kinase activity Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process phosphorylation positive regulation of transcription, DNA-templated cellular response to mechanical stimulus protein phosphorylation regulation of mitotic cell cycle regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10746 26405 Ensembl ENSG00000169967 ENSMUSG00000024383 UniProt Q9Y2U5 Q61083 RefSeq (mRNA) NM_006609 NM_001371910 NM_001371911 NM_011946 RefSeq (protein) NP_006600 NP_001358839 NP_001358840 NP_036076 Location (UCSC) Chr 2: 127.3 – 127.39 Mb Chr 18: 32.3 – 32.37 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.^[7]

Activation

MEKK2 is activated through homodimerization and subsequent trans-autophosphorylation at MEKK2-S519.^[8][9]

MEKK2 is regulated by 14-3-3 proteins which bind to MEKK2-phosphoT283.^[10]

MEKK2 is regulated by SMYD3 which binds and methylates MEKK2-K260.^[11]

Interactions

MAP3K2 has been shown to interact with:

• MAPK8,^[12]
• MAP2K4,^[13]
• MAP2K5,^[14]
• MAP2K7,^[12]
• 14-3-3 protein,^[15]
• SMYD3,^[11]
• SH2D2A,^[14] and
• XIAP^[16]