MAP4K5

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.^[5][6][7]

MAP4K5
Identifiers
Aliases	MAP4K5, GCKR, KHS, KHS1, MAPKKKK5, mitogen-activated protein kinase kinase kinase kinase 5
External IDs	OMIM: 604923; MGI: 1925503; HomoloGene: 38199; GeneCards: MAP4K5; OMA:MAP4K5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 50,418,501 bp[1] End 50,561,126 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,850,524 bp[2] End 69,939,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum sural nerve Achilles tendon tibia canal of the cervix ectocervix body of uterus C1 segment germinal epithelium left ovary Top expressed in secondary oocyte zygote interventricular septum primary oocyte genital tubercle atrium dermis mandibular prominence maxillary prominence atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity protein serine/threonine kinase activity nucleotide binding protein binding ATP binding kinase activity MAP kinase kinase kinase kinase activity Cellular component cytoplasm Biological process protein phosphorylation intracellular signal transduction phosphorylation regulation of mitotic cell cycle regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11183 399510 Ensembl ENSG00000012983 ENSMUSG00000034761 UniProt Q9Y4K4 Q8BPM2 RefSeq (mRNA) NM_006575 NM_198794 NM_201519 RefSeq (protein) NP_006566 NP_942089 NP_958927 Location (UCSC) Chr 14: 50.42 – 50.56 Mb Chr 12: 69.85 – 69.94 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[7]

Interactions

MAP4K5 has been shown to interact with CRKL^[8] and TRAF2.^[9]