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CRKL
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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Crk-like protein is a protein that in humans is encoded by the CRKL gene.[5][6]
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Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.[7]
CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.[8][9]
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Interactions
CRKL has been shown to interact with:
- Abl gene,[10][11][12]
- BCAR1,[13][14]
- BCR gene,[11][15][16][17]
- CBLB,[18]
- CD117,[19][20]
- CD34,[21]
- Cbl gene,[10][20][22][23][24][25][26][27][28][29]
- Dock2,[30]
- EPOR,[22][31]
- GAB1,[32]
- GAB2,[33]
- INPP5D,[31]
- MAP4K1,[34][35][36]
- MAP4K5,[37]
- NEDD9,[10][14][28][38]
- PIK3R2,[20]
- Paxillin[39][40]
- RAPGEF1,[10][22][32][41][42][43][44]
- RICS,[45]
- STAT5A,[46]
- Syk,[47] and
- WAS.[47]
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See also
References
Further reading
External links
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