Melanin-concentrating hormone receptor 1

Melanin-concentrating hormone receptor 1, also known as MCH₁, is one of the melanin-concentrating hormone receptors found in all mammals.^[5]

MCHR1
Identifiers
Aliases	MCHR1, GPR24, MCH-1R, MCH1R, SLC-1, SLC1, melanin concentrating hormone receptor 1
External IDs	OMIM: 601751; MGI: 2180756; HomoloGene: 21097; GeneCards: MCHR1; OMA:MCHR1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 40,679,273 bp[1] End 40,682,812 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 81,119,700 bp[2] End 81,123,165 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 prefrontal cortex superior frontal gyrus entorhinal cortex postcentral gyrus primary visual cortex dorsolateral prefrontal cortex cingulate gyrus Top expressed in lumbar subsegment of spinal cord Paneth cell superior frontal gyrus Region I of hippocampus proper facial motor nucleus primary visual cortex substantia nigra dentate gyrus of hippocampal formation granule cell nucleus accumbens dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity melanin-concentrating hormone receptor activity neuropeptide receptor activity signaling receptor binding protein C-terminus binding hormone binding neuropeptide binding peptide binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane ciliary membrane non-motile cilium cilium Biological process G protein-coupled receptor signaling pathway neuropeptide signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway generation of precursor metabolites and energy feeding behavior signal transduction chemical synaptic transmission cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2847 207911 Ensembl ENSG00000128285 ENSMUSG00000050164 UniProt Q99705 Q8JZL2 RefSeq (mRNA) NM_005297 NM_145132 RefSeq (protein) NP_005288 NP_660114 Location (UCSC) Chr 22: 40.68 – 40.68 Mb Chr 15: 81.12 – 81.12 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.^[5]

Function

MCH₁ is thought to have a number of functions including in the regulation of appetite,^[6][7] and in stress, anxiety and depression.^{[8][9][10][11][12][13]}

Selective ligands

Agonists

• Melanin concentrating hormone (MCH)
• S-36057 - modified MCH 6-13 fragment substituted with 3-iodotyrosine at N-terminus via dioxyoctanoyl linker, used as ¹²⁵I radioligand for mapping MCH₁ in vivo.^[14][15]
• LK-184 (Procter & Gamble) is one pick^[16]

Antagonists

• ATC-0065
• ATC-0175^[17]
• GW-803,430^[18]
• NGD-4715
• SNAP-7941^[19]
• SNAP-94847^[20]
• T-226,296^[21]

See also

• Melanin-concentrating hormone receptor