MED1

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene.^[5][6][7] MED1 functions as a nuclear receptor coactivator.

Med1
Identifiers
Symbol	Med1
Pfam	PF10744
InterPro	IPR019680
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

MED1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RJK, 1RK3, 1RKG, 1RKH, 2O4J, 2O4R, 2ZFX, 3A2H, 3AUN, 3VJS, 3VJT, 3VRT, 3VRU, 3VRV, 3VRW, 3W0G, 3W0H, 3W0I, 3W0J, 3W5P, 3W5Q, 3W5R, 3W5T, 3WT5, 3WT6, 3WT7, 3WTQ, 5AWK, 5AWJ, 4YNK, 5B5B
Identifiers
Aliases	MED1, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2, mediator complex subunit 1
External IDs	OMIM: 604311; MGI: 1100846; HomoloGene: 21002; GeneCards: MED1; OMA:MED1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 39,404,285 bp[1] End 39,451,272 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.75 cM Start 98,042,980 bp[2] End 98,084,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii nipple visceral pleura lower lobe of lung mucosa of paranasal sinus superficial temporal artery parietal pleura trabecular bone human penis buccal mucosa cell Top expressed in Rostral migratory stream cumulus cell spermatocyte spermatid vestibular membrane of cochlear duct hair follicle tail of embryo otic placode internal carotid artery genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding DNA-binding transcription factor activity, RNA polymerase II-specific estrogen receptor binding ubiquitin protein ligase activity transcription factor binding transcription coregulator activity thyroid hormone receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding retinoic acid receptor binding chromatin binding LBD domain binding protein binding nuclear receptor binding vitamin D receptor binding DNA binding mediator complex binding transcription coactivator activity peroxisome proliferator activated receptor binding nuclear receptor coactivator activity chromatin DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription corepressor activity signaling receptor activity Cellular component membrane nucleus mediator complex nucleolus chromatin ubiquitin ligase complex nucleoplasm protein-DNA complex Biological process regulation of RNA biosynthetic process thyroid hormone mediated signaling pathway negative regulation of neuron differentiation regulation of transcription by RNA polymerase II monocyte differentiation embryonic heart tube development androgen biosynthetic process epithelial cell proliferation involved in mammary gland duct elongation enucleate erythrocyte development animal organ regeneration angiogenesis animal organ morphogenesis regulation of transcription, DNA-templated negative regulation of keratinocyte proliferation positive regulation of erythrocyte differentiation regulation of transcription by RNA polymerase I ERK1 and ERK2 cascade in utero embryonic development mammary gland branching involved in pregnancy transcription, DNA-templated positive regulation of transcription, DNA-templated heart development protein ubiquitination camera-type eye development transcription initiation from RNA polymerase II promoter lactation cellular response to steroid hormone stimulus positive regulation of intracellular estrogen receptor signaling pathway peroxisome proliferator activated receptor signaling pathway cellular response to hepatocyte growth factor stimulus positive regulation of keratinocyte differentiation positive regulation of interferon-gamma-mediated signaling pathway positive regulation of G0 to G1 transition embryonic placenta development negative regulation of apoptotic process intracellular steroid hormone receptor signaling pathway negative regulation of transcription by RNA polymerase II retinal pigment epithelium development ventricular trabecula myocardium morphogenesis thyroid hormone generation fat cell differentiation positive regulation of hepatocyte proliferation megakaryocyte development androgen receptor signaling pathway positive regulation of mammary gland epithelial cell proliferation mammary gland epithelial cell proliferation mammary gland branching involved in thelarche regulation of vitamin D receptor signaling pathway mRNA transcription by RNA polymerase II keratinocyte differentiation regulation of cell cycle cellular response to epidermal growth factor stimulus multicellular organism development positive regulation of signaling receptor activity brain development positive regulation of gene expression lens development in camera-type eye cell morphogenesis embryonic hemopoiesis cellular response to thyroid hormone stimulus positive regulation of cell population proliferation liver development positive regulation of transcription by RNA polymerase II erythrocyte development embryonic hindlimb morphogenesis regulation of lipid metabolic process protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5469 19014 Ensembl ENSG00000125686 ENSMUSG00000018160 UniProt Q15648 Q925J9 RefSeq (mRNA) NM_004774 NM_001080118 NM_013634 NM_134027 NM_001361950 NM_001361951 RefSeq (protein) NP_004765 NP_001073587 NP_038662 NP_598788 NP_001348879 NP_001348880 Location (UCSC) Chr 17: 39.4 – 39.45 Mb Chr 11: 98.04 – 98.08 Mb PubMed search [3] [4]
Wikidata
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Function

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The mediator of RNA polymerase II transcription subunit 1 protein is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes [e.g., thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors]. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.^[7]

Interactions

MED1 has been shown to interact with:

• Androgen receptor,^[8]
• Calcitriol receptor,^[9][10]
• Cyclin-dependent kinase 8,^[9][11]
• Estrogen receptor alpha,^[10][11]
• Glucocorticoid receptor,^[12][13]
• Hepatocyte nuclear factor 4 alpha,^[14][15]
• P53,^[16][17]
• PPARGC1A,^[18]
• TGS1,^[19] and
• Thyroid hormone receptor alpha.^[20]

Protein family

This entry represents subunit Med1 of the Mediator complex. The Med1 forms part of the Med9 submodule of the Srb/Med complex. It is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions.^[21]