TGS1

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.^[5][6][7]

TGS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EGI, 3GDH
Identifiers
Aliases	TGS1, NCOA6IP, PIMT, PIPMT, trimethylguanosine synthase 1
External IDs	OMIM: 606461; MGI: 2151797; HomoloGene: 32608; GeneCards: TGS1; OMA:TGS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.1 Start 55,773,446 bp[1] End 55,826,445 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A1|4 1.99 cM Start 3,574,875 bp[2] End 3,616,619 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii oocyte secondary oocyte Achilles tendon nipple tail of epididymis pylorus internal globus pallidus renal medulla corpus epididymis Top expressed in tail of embryo condyle cumulus cell genital tubercle ureter primitive streak pineal gland renal corpuscle fossa abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity RNA trimethylguanosine synthase activity protein binding RNA methyltransferase activity Cellular component cytoplasm Cajal body nucleoplasm nucleolus small nuclear ribonucleoprotein complex nucleus extracellular space cytosol Biological process regulation of transcription, DNA-templated transcription, DNA-templated spliceosomal snRNP assembly methylation 7-methylguanosine RNA capping 7-methylguanosine cap hypermethylation ribonucleoprotein complex biogenesis RNA methylation regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 96764 116940 Ensembl ENSG00000137574 ENSMUSG00000028233 UniProt Q96RS0 Q923W1 RefSeq (mRNA) NM_024831 NM_001317902 NM_001363184 NM_054089 RefSeq (protein) NP_001304831 NP_079107 NP_001350113 NP_473430 Location (UCSC) Chr 8: 55.77 – 55.83 Mb Chr 4: 3.57 – 3.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TGS1 has been shown to interact with:

• CREB-binding protein,^[8] and
• EED,^[9]
• EP300,^[8]
• MED1,^[8] and
• NCOA6.^[5][8]