MED25

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.^[5][6][7]

MED25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KY6, 2L6U, 2XNF, 2L23
Identifiers
Aliases	MED25, ACID1, ARC92, CMT2B2, P78, PTOV2, BVSYS, TCBAP0758, mediator complex subunit 25
External IDs	OMIM: 610197; MGI: 1922863; HomoloGene: 12614; GeneCards: MED25; OMA:MED25 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,818,282 bp[1] End 49,840,383 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.95 cM Start 44,876,765 bp[2] End 44,892,712 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right testis left testis right adrenal cortex right uterine tube left adrenal cortex blood muscle of thigh bronchial epithelial cell Top expressed in ventricular zone muscle of thigh yolk sac dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex lip epiblast spermatid molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding protein binding retinoic acid receptor binding retinoid X receptor binding Cellular component nucleus nucleoplasm mediator complex Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of chromatin binding negative regulation of fibroblast proliferation positive regulation of mediator complex assembly positive regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81857 75613 Ensembl ENSG00000104973 ENSMUSG00000002968 UniProt Q71SY5 Q8VCB2 RefSeq (mRNA) NM_030973 NM_001378355 NM_029365 NM_001331206 NM_001331207 NM_001331208 RefSeq (protein) NP_112235 NP_001365284 NP_001318135 NP_001318136 NP_001318137 NP_083641 Location (UCSC) Chr 19: 49.82 – 49.84 Mb Chr 7: 44.88 – 44.89 Mb PubMed search [3] [4]
Wikidata
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Intellectual developmental disorder

A homozygous variant in the MED25 gene, leading to an arginine to trypsin substitution, was identified in seven individuals with impaired intellectual development and characteristic facial features.^[8] The genetic variant segregated with the disorder and was not found in control populations. This putative homozygous variant arose 218 years ago in this Brazilian family.^[9]

Interactions

MED25 has been shown to interact with MED4.^[10]