MED4

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.^[5][6][7]

MED4
Identifiers
Aliases	MED4, ARC36, DRIP36, HSPC126, TRAP36, VDRIP, mediator complex subunit 4
External IDs	OMIM: 605718; MGI: 1914631; HomoloGene: 8568; GeneCards: MED4; OMA:MED4 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.2 Start 48,053,323 bp[1] End 48,095,131 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 73,747,465 bp[2] End 73,756,289 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gingival epithelium palpebral conjunctiva germinal epithelium rectum monocyte epithelium of nasopharynx testicle right testis tibial arteries Top expressed in primary oocyte interventricular septum morula ventricular zone embryo embryo epiblast abdominal wall primitive streak medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thyroid hormone receptor binding protein binding transcription coregulator activity nuclear receptor coactivator activity vitamin D receptor binding signaling receptor activity Cellular component core mediator complex membrane nucleus mediator complex nucleoplasm Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated androgen receptor signaling pathway intracellular steroid hormone receptor signaling pathway regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated transcription initiation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29079 67381 Ensembl ENSG00000136146 ENSMUSG00000022109 UniProt Q9NPJ6 Q9CQA5 RefSeq (mRNA) NM_014166 NM_001270629 NM_026119 RefSeq (protein) NP_001257558 NP_054885 NP_080395 Location (UCSC) Chr 13: 48.05 – 48.1 Mb Chr 14: 73.75 – 73.76 Mb PubMed search [3] [4]
Wikidata
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Med4
Identifiers
Symbol	Med4
Pfam	PF10018
InterPro	IPR019258
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

The protein encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.^[6]

Interactions

MED4 has been shown to interact with MED25.^[8]