MED6

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.^[5][6][7]

MED6
Identifiers
Aliases	MED6, ARC33, NY-REN-28, mediator complex subunit 6
External IDs	OMIM: 602984; MGI: 1917042; HomoloGene: 3990; GeneCards: MED6; OMA:MED6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.2 Start 70,581,257 bp[1] End 70,600,690 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 81,620,331 bp[2] End 81,641,782 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon testicle islet of Langerhans monocyte skin of leg skin of abdomen ganglionic eminence muscle of thigh gastrocnemius muscle rectum Top expressed in zygote genital tubercle tail of embryo yolk sac morula neural layer of retina interventricular septum maxillary prominence mandibular prominence epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription coregulator activity transcription factor binding protein binding Cellular component mediator complex core mediator complex membrane nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10001 69792 Ensembl ENSG00000133997 ENSMUSG00000002679 UniProt O75586 Q921D4 RefSeq (mRNA) NM_005466 NM_001284209 NM_001284210 NM_001284211 NM_027213 NM_001347384 NM_001347385 NM_001347386 RefSeq (protein) NP_001271138 NP_001271139 NP_001271140 NP_005457 NP_001334313 NP_001334314 NP_001334315 Location (UCSC) Chr 14: 70.58 – 70.6 Mb Chr 12: 81.62 – 81.64 Mb PubMed search [3] [4]
Wikidata
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Med6
Identifiers
Symbol	Med6
Pfam	PF04934
InterPro	IPR007018
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Protein family

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.^[5]

Interactions

MED6 has been shown to interact with:

• Cyclin-dependent kinase 8,^{[8][9][10][11]}
• Estrogen receptor alpha,^[11]
• MED21,^[12] and
• Thyroid hormone receptor alpha.^[10]