MFAP5

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.^[5][6][7]

MFAP5
Identifiers
Aliases	MFAP5, MAGP-2, MAGP2, MFAP-5, MP25, AAT9, microfibrillar associated protein 5, microfibril associated protein 5
External IDs	OMIM: 601103; MGI: 1354387; HomoloGene: 2599; GeneCards: MFAP5; OMA:MFAP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 8,637,346 bp[1] End 8,662,888 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 122,482,804 bp[2] End 122,506,249 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint skin of hip tibial nerve smooth muscle tissue pericardium placenta right coronary artery vena cava urethra decidua Top expressed in decidua gastrula ascending aorta sciatic nerve aortic valve cervix ankle esophagus intercostal muscle extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent Cellular component extracellular region microfibril extracellular matrix collagen-containing extracellular matrix Biological process definitive hemopoiesis extracellular matrix organization supramolecular fiber organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8076 50530 Ensembl ENSG00000197614 ENSMUSG00000030116 UniProt Q13361 Q9QZJ6 RefSeq (mRNA) NM_001297709 NM_001297710 NM_001297711 NM_001297712 NM_003480 NM_015776 NM_001347434 RefSeq (protein) NP_001284638 NP_001284639 NP_001284640 NP_001284641 NP_003471 NP_001334363 NP_056591 Location (UCSC) Chr 12: 8.64 – 8.66 Mb Chr 6: 122.48 – 122.51 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.^[7]