MAP3K11

"MLK3" redirects here. For the American activist, see Martin Luther King III.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.^[5][6]

MAP3K11
Identifiers
Aliases	MAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK, mitogen-activated protein kinase kinase kinase 11
External IDs	OMIM: 600050; MGI: 1346880; HomoloGene: 37618; GeneCards: MAP3K11; OMA:MAP3K11 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,597,756 bp[1] End 65,615,382 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 5,738,770 bp[2] End 5,752,893 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte apex of heart mucosa of transverse colon right lobe of liver monocyte right lung spleen C1 segment upper lobe of left lung Top expressed in granulocyte yolk sac lip external carotid artery internal carotid artery intestinal villus right kidney thymus crypt of lieberkuhn of small intestine zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein homodimerization activity mitogen-activated protein kinase kinase kinase binding kinase activity protein binding identical protein binding mitogen-activated protein kinase kinase binding ATP binding MAP kinase kinase kinase activity protein serine/threonine kinase activity protein kinase activity JUN kinase kinase kinase activity protein tyrosine kinase activity Cellular component centrosome membrane microtubule organizing center microtubule cytoskeleton cytoplasm intracellular anatomical structure Biological process phosphorylation positive regulation of JUN kinase activity cell death positive regulation of JNK cascade positive regulation of neuron apoptotic process microtubule-based process cell population proliferation protein autophosphorylation JNK cascade protein phosphorylation positive regulation of apoptotic process MAPK cascade peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4296 26403 Ensembl ENSG00000173327 ENSMUSG00000004054 UniProt Q16584 Q80XI6 RefSeq (mRNA) NM_002419 NM_022012 RefSeq (protein) NP_002410 NP_002410.1 NP_071295 Location (UCSC) Chr 11: 65.6 – 65.62 Mb Chr 19: 5.74 – 5.75 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.^[7][8]

Interactions

MAP3K11 has been shown to interact with:

• AKT1,^[9]
• CDC42,^[10][11]
• MAPK8IP1,^[12]
• MAPK8IP2,^[12] and
• SH3RF1.^[13]