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SH3RF1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

SH3RF1
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Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.[5][6]

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Function

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[6]

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Interactions

SH3RF1 has been shown to interact with AKT2[7] and MAP3K11.[7]

References

Further reading

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