MN-18

MN-18
Legal status
Legal status	CA: Schedule II; DE: NpSG (Industrial and scientific use only); UK: Class B;
Identifiers
	IUPAC name N-(naphthalen-1-yl)-1-pentyl-1H-indazole-3-carboxamide;
CAS Number	1391484-80-2 ;
PubChem CID	119058030;
ChemSpider	29763729;
UNII	GP2N1PG5X2;
CompTox Dashboard (EPA)	DTXSID301010033 ;
Chemical and physical data
Formula	C23H23N3O
Molar mass	357.457 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCn1nc(c2c1cccc2)C(=O)Nc1cccc2c1cccc2;
	InChI InChI=1S/C23H23N3O/c1-2-3-8-16-26-21-15-7-6-13-19(21)22(25-26)23(27)24-20-14-9-11-17-10-4-5-12-18(17)20/h4-7,9-15H,2-3,8,16H2,1H3,(H,24,27); Key:UJKHLVOEXULDRU-UHFFFAOYSA-N;

MN 18 is an indazole-based synthetic cannabinoid that is an agonist for the cannabinoid receptors, with K_i values of 45.72 nM at CB₁ and 11.098 nM at CB₂ and EC₅₀ values of 2.028 nM at CB₁ and 1.233 nM at CB₂,^[1] and has been sold online as a designer drug.^[2]^[3] It is the indazole core analogue of NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of MN-18 may release 1-naphthylamine, a known carcinogen. MN-18 metabolism has been described in literature.^[4]^[5]

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MN-18

Legal status

See also

References

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