FUB-APINACA

FUB-APINACA (also known as A-FUBINACA according to the EMCCDA framework for naming synthetic cannabinoids^[1] and FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[2] It is an analog of APINACA and 5F-APINACA where the pentyl chain has been replaced with fluorobenzyl.

FUB-APINACA

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B US: Schedule I
Identifiers
IUPAC name N-(Adamantan-1-yl)-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide
CAS Number	2180933-90-6 Y
PubChem CID	118796517
ChemSpider	30922497
UNII	OF9Q7PH4UD
CompTox Dashboard (EPA)	DTXSID101336146
Chemical and physical data
Formula	C25H26FN3O
Molar mass	403.501 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(NC1(C[C@H]2C3)C[C@H]3C[C@H](C2)C1)C4=NN(CC5=CC=C(F)C=C5)C6=C4C=CC=C6
InChI InChI=1S/C25H26FN3O/c26-20-7-5-16(6-8-20)15-29-22-4-2-1-3-21(22)23(28-29)24(30)27-25-12-17-9-18(13-25)11-19(10-17)14-25/h1-8,17-19H,9-15H2,(H,27,30)/t17-,18+,19-,25? Key:MWBHSNBPUSKVDD-LPSAYFBNSA-N

Pharmacology

FUB-APINACA acts as a full agonist with a binding affinity of 1.06 nM at CB₁ and 0.174 nM at CB₂ cannabinoid receptors.^[3]

Legal status

In the United States, FUB-APINACA was temporarily emergency scheduled by the DEA in 2019.^[4] and made a permanent Schedule I Controlled Substance nationwide on April 7, 2022.^[5] Previously, it was illegal only in Alabama (listed as FUB-AKB48).^[6]

Sweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.^[7]

See also

• 5F-ADB
• 5F-AMB
• AB-FUBINACA
• AB-CHFUPYCA
• AB-PINACA
• ADAMANTYL-THPINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APP-FUBINACA
• FAB-144
• MDMB-CHMINACA
• MDMB-FUBINACA
• PX-3