MOGAT2

2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2 gene.

MOGAT2
Identifiers
Aliases	MOGAT2, DGAT2L5, MGAT2, DGAT2L5., hDC5, monoacylglycerol O-acyltransferase 2
External IDs	OMIM: 610270; MGI: 2663253; HomoloGene: 57020; GeneCards: MOGAT2; OMA:MOGAT2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 75,717,838 bp[1] End 75,732,958 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 98,868,291 bp[2] End 98,887,826 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of transverse colon right lobe of liver testicle rectum jejunal mucosa duodenum mucosa of sigmoid colon epithelium of colon appendix Top expressed in epithelium of small intestine intestinal villus ileum jejunum yolk sac duodenum primitive streak migratory enteric neural crest cell epiblast somite More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups 2-acylglycerol O-acyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process intestinal absorption glycerol metabolic process diacylglycerol biosynthetic process lipid metabolism triglyceride biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80168 233549 Ensembl ENSG00000166391 ENSMUSG00000052396 UniProt Q3SYC2 Q80W94 RefSeq (mRNA) NM_025098 NM_177448 RefSeq (protein) NP_079374 NP_803231 Location (UCSC) Chr 11: 75.72 – 75.73 Mb Chr 7: 98.87 – 98.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MOGAT2 and the related MOGAT3 genes are members of the acylglycerol o-acyltransferase family (DGAT2/MOGAT) and are involved in the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG) from monoacylglycerol (MAG).

MOGAT2 and also MOGAT3 are single copy genes in almost all mammals. However, in ruminants both genes have undergone tandem gene expansion, indicate of evolving functionality. MOGAT2 has more than five tandemly duplicated copies in sheep with the first copy expressed in the duodenum and the last copy expressed in the skin, with no expression of any copy detected in the liver.^[5][6][7]