MPDZ

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.^[5]

MPDZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FCF, 2FNE, 2IWN, 2IWO, 2IWP, 2IWQ, 2O2T, 2OPG, 2QG1
Identifiers
Aliases	MPDZ, HYC2, MUPP1, multiple PDZ domain crumbs cell polarity complex component
External IDs	OMIM: 603785; MGI: 1343489; HomoloGene: 2841; GeneCards: MPDZ; OMA:MPDZ - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p23 Start 13,105,704 bp[1] End 13,279,590 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C3|4 38.0 cM Start 81,278,500 bp[2] End 81,442,815 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum ventricular zone subthalamic nucleus inferior ganglion of vagus nerve Epithelium of choroid plexus external globus pallidus superior vestibular nucleus vena cava pars reticulata Top expressed in epithelium of lens tail of embryo vestibular sensory epithelium digastric muscle neural layer of retina sciatic nerve genital tubercle vastus lateralis muscle iris efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding Cellular component cytoplasm neuron projection cell junction apicolateral plasma membrane dendrite postsynaptic membrane plasma membrane cell projection synapse apical plasma membrane Schmidt-Lanterman incisure cytoplasmic vesicle postsynaptic density membrane bicellular tight junction Biological process cell adhesion viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8777 17475 Ensembl ENSG00000107186 ENSMUSG00000028402 UniProt O75970 Q8VBX6 RefSeq (mRNA) NM_001261406 NM_001261407 NM_003829 NM_001330637 NM_010820 NM_001305284 NM_001305286 RefSeq (protein) NP_001248335 NP_001248336 NP_001317566 NP_003820 NP_001362342 NP_001362345 NP_001362346 NP_001362347 NP_001362348 NP_001362349 NP_001362350 NP_001362351 NP_001362352 NP_001362353 NP_001362354 NP_001362355 NP_001362356 NP_001365707 NP_001292213 NP_001292215 NP_034950 Location (UCSC) Chr 9: 13.11 – 13.28 Mb Chr 4: 81.28 – 81.44 Mb PubMed search [3] [4]
Wikidata
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Interactions

MPDZ has been shown to interact with:

• 5-HT2C receptor,^[6][7]
• CD117,^[8] and
• PLEKHA1.^[9]