PLEKHA1

Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.^[5][6][7]

PLEKHA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EAZ
Identifiers
Aliases	PLEKHA1, TAPP1, pleckstrin homology domain containing A1
External IDs	OMIM: 607772; MGI: 2442213; HomoloGene: 11001; GeneCards: PLEKHA1; OMA:PLEKHA1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.13 Start 122,374,696 bp[1] End 122,442,602 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 130,467,486 bp[2] End 130,515,042 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh sperm Brodmann area 23 skin of hip middle temporal gyrus postcentral gyrus gingival epithelium synovial joint endothelial cell primary visual cortex Top expressed in neural layer of retina decidua gastrula ciliary body olfactory bulb iris pineal gland CA3 field perirhinal cortex sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding phosphatidylinositol-3,4-bisphosphate binding protein binding lipid binding Cellular component cytoplasm membrane nucleoplasm ruffle membrane extracellular exosome nucleus cytosol plasma membrane Biological process B cell receptor signaling pathway roof of mouth development negative regulation of protein kinase B signaling luteinization Leydig cell differentiation estrogen metabolic process androgen metabolic process ruffle organization multicellular organism growth establishment of protein localization skeletal system morphogenesis post-embryonic development female gonad development spermatogenesis phosphatidylinositol 3-kinase signaling platelet-derived growth factor receptor signaling pathway face morphogenesis cellular response to hydrogen peroxide phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59338 101476 Ensembl ENSG00000107679 ENSMUSG00000040268 UniProt Q9HB21 Q8BUL6 RefSeq (mRNA) NM_001001974 NM_001195608 NM_021622 NM_001330178 NM_133942 NM_001346515 NM_001357696 NM_001382373 NM_001382374 NM_001382375 NM_001382376 NM_001382377 NM_001382378 NM_001382379 RefSeq (protein) NP_001001974 NP_001182537 NP_001317107 NP_067635 NP_001364159 NP_001364160 NP_001364161 NP_001364163 NP_001364164 NP_001364166 NP_001364167 NP_001364169 NP_001364170 NP_001364171 NP_001364172 NP_001364173 NP_001364174 NP_001364175 NP_001364176 NP_001364177 NP_001364178 NP_001364179 NP_001364180 NP_001364181 NP_001364182 NP_001364183 NP_001364184 NP_001364185 NP_001364186 NP_001364187 NP_001333444 NP_598703 NP_001344625 NP_001369302 NP_001369303 NP_001369304 NP_001369305 NP_001369306 NP_001369307 NP_001369308 Location (UCSC) Chr 10: 122.37 – 122.44 Mb Chr 7: 130.47 – 130.52 Mb PubMed search [3] [4]
Wikidata
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Interactions

PLEKHA1 has been shown to interact with MPDZ.^[8]