Moesin

Moesin is a protein that in humans is encoded by the MSN gene.^[5][6]

MSN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E5W, 1EF1, 1SGH
Identifiers
Aliases	MSN, HEL70, moesin, IMD50
External IDs	OMIM: 309845; MGI: 97167; HomoloGene: 1833; GeneCards: MSN; OMA:MSN - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq12 Start 65,588,377 bp[1] End 65,741,931 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 95,139,648 bp[2] End 95,212,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung white blood cell monocyte granulocyte synovial joint saphenous vein synovial membrane right lung appendix smooth muscle tissue Top expressed in right lung right lung lobe left lung endothelial cell of lymphatic vessel left lung lobe granulocyte mesenteric lymph nodes stroma of bone marrow ascending aorta tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal protein binding structural constituent of cytoskeleton protein binding actin binding double-stranded RNA binding signaling receptor binding protein kinase binding cell adhesion molecule binding enzyme binding Cellular component cytoplasm vesicle cell projection pseudopodium blood microparticle membrane focal adhesion filopodium myelin sheath plasma membrane apical part of cell microvillus uropod basolateral plasma membrane apical plasma membrane perinuclear region of cytoplasm extracellular exosome cytoskeleton microvillus membrane nucleus cell periphery extracellular space cell surface cytosol Biological process leukocyte cell-cell adhesion regulation of cell size establishment of endothelial barrier regulation of organelle assembly cellular response to testosterone stimulus regulation of lymphocyte migration positive regulation of podosome assembly gland morphogenesis positive regulation of gene expression establishment of epithelial cell apical/basal polarity regulation of cell shape membrane to membrane docking positive regulation of protein localization to early endosome positive regulation of early endosome to late endosome transport leukocyte migration cytoskeleton organization immunological synapse formation T cell proliferation T cell aggregation T cell migration interleukin-12-mediated signaling pathway viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4478 17698 Ensembl ENSG00000147065 ENSMUSG00000031207 UniProt P26038 P26041 RefSeq (mRNA) NM_002444 NM_010833 RefSeq (protein) NP_002435 NP_034963 Location (UCSC) Chr X: 65.59 – 65.74 Mb Chr X: 95.14 – 95.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons.^[7]

Moesin is localized to filopodia and other membranous protrusions that are important for cell–cell recognition and signaling and for cell movement.^[7]

Moesin has FERM domain at N-terminal.

Interactions

Moesin has been shown to interact with:

• CD43^[8][9]
• ICAM3^[10][11]
• Neutrophil cytosolic factor 1,^[12]
• Neutrophil cytosolic factor 4^[12]
• VCAM-1^[13]
• EZR^[14][15][16]