MST1

For mammalian sterile 20–like kinase-1, see STK4.

Not to be confused with Macrophage colony-stimulating factor.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene.^[5][6][7]

MST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ASU, 4QT8
Identifiers
Aliases	MST1, D3F15S2, DNF15S2, HGFL, MSP, NF15S2, macrophage stimulating 1
External IDs	OMIM: 142408; MGI: 96080; HomoloGene: 7360; GeneCards: MST1; OMA:MST1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,683,947 bp[1] End 49,689,501 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 59.07 cM Start 107,957,635 bp[2] End 107,962,202 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum left testis left lobe of thyroid gland right testis right lobe of thyroid gland human kidney right uterine tube pituitary gland left adrenal cortex Top expressed in left lobe of liver liver parenchyma fetal liver hematopoietic progenitor cell ankle joint embryo transitional epithelium of urinary bladder embryo esophagus lip corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding protein binding serine-type endopeptidase activity Cellular component extracellular region extracellular space collagen-containing extracellular matrix Biological process proteolysis regulation of cAMP-dependent protein kinase activity hepatocyte growth factor receptor signaling pathway negative regulation of gluconeogenesis regulation of macrophage chemotaxis positive regulation of mammary gland epithelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4485 15235 Ensembl ENSG00000173531 ENSMUSG00000032591 UniProt P26927 P26928 RefSeq (mRNA) NM_020998 NM_001393581 NM_001393582 NM_001393583 NM_001393584 NM_001393585 NM_008243 RefSeq (protein) NP_066278 NP_032269 Location (UCSC) Chr 3: 49.68 – 49.69 Mb Chr 9: 107.96 – 107.96 Mb PubMed search [3] [4]
Wikidata
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