MTPN

Myotrophin is a protein that in humans is encoded by the MTPN gene.^[5][6]

MTPN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AAA
Identifiers
Aliases	MTPN, GCDP, V-1, myotrophin
External IDs	OMIM: 606484; MGI: 99445; HomoloGene: 40607; GeneCards: MTPN; OMA:MTPN - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 135,926,760 bp[1] End 135,977,359 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 35,485,841 bp[2] End 35,516,823 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium skin of arm mucosa of ileum myocardium of left ventricle superficial temporal artery monocyte lower lobe of lung trabecular bone Brodmann area 46 tibialis anterior muscle Top expressed in retinal pigment epithelium Rostral migratory stream barrel cortex ciliary body epithelium of lens dorsal striatum endothelial cell of lymphatic vessel subiculum prefrontal cortex pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding Cellular component cytoplasm F-actin capping protein complex axon perinuclear region of cytoplasm nucleus cytosol Biological process regulation of striated muscle tissue development catecholamine metabolic process positive regulation of cardiac muscle hypertrophy regulation of barbed-end actin filament capping cellular response to mechanical stimulus skeletal muscle tissue regeneration neuron differentiation striated muscle cell differentiation regulation of translation cerebellar granule cell differentiation positive regulation of NF-kappaB transcription factor activity positive regulation of cell growth positive regulation of macromolecule biosynthetic process regulation of cell size Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 136319 14489 Ensembl ENSG00000105887 ENSMUSG00000029840 UniProt P58546 P62774 RefSeq (mRNA) NM_145808 NM_008098 RefSeq (protein) NP_665807 NP_032124 Location (UCSC) Chr 7: 135.93 – 135.98 Mb Chr 6: 35.49 – 35.52 Mb PubMed search [3] [4]
Wikidata
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Interactions

MTPN has been shown to interact with RELA^[7] and REL.^[7]