MYH1

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene.^[5][6] This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.

MYH1
Identifiers
Aliases	MYH1, HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x, myosin, heavy chain 1, skeletal muscle, adult, myosin heavy chain 1
External IDs	OMIM: 160730; MGI: 1339711; HomoloGene: 133718; GeneCards: MYH1; OMA:MYH1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 10,492,307 bp[1] End 10,518,542 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 40.59 cM Start 67,090,878 bp[2] End 67,115,401 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii vastus lateralis muscle Skeletal muscle tissue of biceps brachii muscle of thigh thoracic diaphragm gastrocnemius muscle deltoid muscle triceps brachii muscle larynx Top expressed in masseter muscle digastric muscle intercostal muscle extraocular muscle ankle temporal muscle tibialis anterior muscle vastus lateralis muscle sternocleidomastoid muscle body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding actin binding cytoskeletal motor activity protein binding ATP binding calmodulin binding actin filament binding microtubule motor activity microtubule binding Cellular component cytoplasm myosin filament cytoplasmic ribonucleoprotein granule myofibril myosin complex muscle myosin complex intercalated disc A band Biological process microtubule-based movement muscle contraction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4619 17879 Ensembl ENSG00000109061 ENSMUSG00000056328 UniProt P12882 Q5SX40 RefSeq (mRNA) NM_005963 NM_030679 RefSeq (protein) NP_005954 NP_109604 Location (UCSC) Chr 17: 10.49 – 10.52 Mb Chr 11: 67.09 – 67.12 Mb PubMed search [3] [4]
Wikidata
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Function

Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, but rarely in non-muscle cells. These isoforms show expression that is spatially and temporally regulated during development.^[6]