MYLIP

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.^[5]

MYLIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YHN, 2YHO
Identifiers
Aliases	MYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDs	OMIM: 610082; MGI: 2388271; HomoloGene: 8309; GeneCards: MYLIP; OMA:MYLIP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 16,129,086 bp[1] End 16,148,248 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 45,543,218 bp[2] End 45,565,498 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte nipple lower lobe of lung lactiferous duct synovial joint renal medulla saphenous vein urethra cardia Top expressed in calvaria lymph node transitional epithelium of urinary bladder ciliary body tibiofemoral joint parotid gland sciatic nerve mesenteric lymph nodes skin of external ear iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding cytoskeletal protein binding protein binding ubiquitin-protein transferase activity structural constituent of cytoskeleton transferase activity ubiquitin protein ligase activity Cellular component cytoplasm membrane plasma membrane intracellular anatomical structure cytosol cytoskeleton Biological process positive regulation of protein catabolic process negative regulation of low-density lipoprotein particle clearance regulation of low-density lipoprotein particle receptor catabolic process nervous system development protein destabilization protein ubiquitination cholesterol homeostasis protein polyubiquitination actomyosin structure organization low-density lipoprotein particle receptor catabolic process negative regulation of neuron projection development ubiquitin-dependent protein catabolic process cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29116 218203 Ensembl ENSG00000007944 ENSMUSG00000038175 UniProt Q8WY64 Q8BM54 RefSeq (mRNA) NM_013262 NM_153789 RefSeq (protein) NP_037394 NP_722484 Location (UCSC) Chr 6: 16.13 – 16.15 Mb Chr 13: 45.54 – 45.57 Mb PubMed search [3] [4]
Wikidata
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MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation or MIR "Modulator Of Immune Recognition".^[6][7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.^[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.^[5]