Major vault protein

Major vault protein, also known as lung resistance-related protein is a protein that in humans is encoded by the MVP gene.^[5][6] 78 copies of the protein assemble into the large compartments called vaults.

MVP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y7X
Identifiers
Aliases	MVP, LRP, VAULT1, major vault protein, lung resistance-related protein
External IDs	OMIM: 605088; MGI: 1925638; HomoloGene: 3752; GeneCards: MVP; OMA:MVP - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,820,394 bp[1] End 29,848,039 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,586,032 bp[2] End 126,613,793 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right adrenal gland left adrenal gland left adrenal cortex granulocyte right adrenal cortex epithelium of colon upper lobe of left lung stromal cell of endometrium right ovary Top expressed in ankle joint duodenum intestinal villus Ileal epithelium jejunum granulocyte colon yolk sac lip membranous bone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding protein binding protein kinase binding identical protein binding Cellular component cytoplasm perinuclear region of cytoplasm nuclear pore extracellular exosome cytoskeleton membrane nucleus extracellular region cytosol secretory granule lumen ficolin-1-rich granule lumen Biological process protein transport mRNA transport negative regulation of protein tyrosine kinase activity ERBB signaling pathway negative regulation of signaling negative regulation of protein autophosphorylation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9961 78388 Ensembl ENSG00000013364 ENSMUSG00000030681 UniProt Q14764 Q9EQK5 RefSeq (mRNA) NM_017458 NM_001293204 NM_001293205 NM_005115 NM_080638 RefSeq (protein) NP_001280133 NP_001280134 NP_005106 NP_059447 NP_001280134.1 NP_542369 Location (UCSC) Chr 16: 29.82 – 29.85 Mb Chr 7: 126.59 – 126.61 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. Major vault protein comprises 70% of vaults which also contain vPARP and TEP1.^[7] This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.^[6]

Interactions

Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases major vault protein associated with the estrogen receptor in nuclear extracts.^[8]

Major vault protein has been shown to interact with estrogen receptor alpha,^[9] PTEN^[10] and PARP4.^[11][12]