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Monooxygenase DBH-like 1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Monooxygenase DBH-like 1
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DBH-like monooxygenase protein 1, also known as monooxygenase X, is an enzyme that in humans is encoded by the MOXD1 gene.[5][6]

Quick Facts MOXD1, Identifiers ...

DBH-like 1 maintains many of the structural features of dopamine beta-monooxygenase DBH.[7] Since Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) is homologous to dopamine beta-monooxygenase (DBM; EC 1.14.17.1)[8] this concerns a structural basis for a new family of copper type II, significantly specific for ascorbate-dependent monooxygenases[8] based on the corresponding mouse homolog.[6] The pathway of catecholamine synthesis is a possible catecholamine-binding metabolic copper[9] enzyme domain, a neuron-like property encoding MOX without a signal sequence enzyme metabolism resolving the monooxygenase X chemical pathway[9] of an unknown substrate,[6] exogenous MOX is not secreted, and it localizes throughout the endoplasmic reticulum,[9] in both endocrine or nonendocrine cells.[9]

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Deficiency

DBH deficiency has been treated effectively with L-threo-3,4-dihydroxyphenylserine (DOPS).[10]

See also

  • Dopamine-beta-hydroxylase-DBH,
  • Dopamine beta-monooxygenase-DBM,
  • Peptidylglycine alpha-hydroxylating monooxygenase-PHM
  • peptidyl-alpha-hydroxyglycine alpha-amidating lyase-PAL
  • Tyrosine 3-monooxygenase-TH.

References

Further reading

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