NCKAP1

Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.^[5][6][7][8]

NCKAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P8C, 4N78
Identifiers
Aliases	NCKAP1, HEM2, NAP1, NAP125, p125Nap1, NCK associated protein 1
External IDs	OMIM: 604891; MGI: 1355333; HomoloGene: 8384; GeneCards: NCKAP1; OMA:NCKAP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.1 Start 182,909,115 bp[1] End 183,038,858 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 48.21 cM Start 80,330,856 bp[2] End 80,411,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula frontal pole skin of arm Epithelium of choroid plexus cerebellar vermis ganglionic eminence ventricular zone lateral nuclear group of thalamus oral cavity orbitofrontal cortex Top expressed in CA3 field Region I of hippocampus proper cingulate gyrus dorsal striatum amygdala hippocampus proper primary motor cortex substantia nigra central gray substance of midbrain nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding protein binding Cellular component integral component of membrane cytosol cell projection membrane SCAR complex focal adhesion plasma membrane extracellular exosome lamellipodium membrane ruffle lamellipodium filamentous actin Biological process Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of Arp2/3 complex-mediated actin nucleation central nervous system development vascular endothelial growth factor receptor signaling pathway Rac protein signal transduction viral process apoptotic process positive regulation of lamellipodium assembly positive regulation of actin filament polymerization cell morphogenesis cell migration cell projection assembly cortical actin cytoskeleton organization neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10787 50884 Ensembl ENSG00000061676 ENSMUSG00000027002 UniProt Q9Y2A7 P28660 RefSeq (mRNA) NM_013436 NM_205842 NM_001290745 NM_016965 NM_001355410 NM_001355411 RefSeq (protein) NP_038464 NP_995314 NP_001277674 NP_058661 NP_001342339 NP_001342340 Location (UCSC) Chr 2: 182.91 – 183.04 Mb Chr 2: 80.33 – 80.41 Mb PubMed search [3] [4]
Wikidata
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Interactions

NCKAP1 has been shown to interact with RAC1^[9] and ABI1.^[10]