Nuclear receptor co-repressor 1

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.^[5][6]

NCOR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EQR, 3H52, 3KMZ, 3N00, 4MDD, 4WVD
Identifiers
Aliases	NCOR1, N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR, nuclear receptor corepressor 1
External IDs	OMIM: 600849; MGI: 1349717; HomoloGene: 38166; GeneCards: NCOR1; OMA:NCOR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p12-p11.2 Start 16,029,157 bp[1] End 16,218,185 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 62,207,252 bp[2] End 62,349,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve epithelium of colon Achilles tendon ventricular zone testicle gonad mucosa of transverse colon buccal mucosa cell ganglionic eminence corpus callosum Top expressed in tail of embryo genital tubercle neural layer of retina otic vesicle Rostral migratory stream lacrimal gland saccule granulocyte epithelium of small intestine thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity histone deacetylase binding thyroid hormone receptor binding protein binding nuclear receptor binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding sequence-specific DNA binding Cellular component histone deacetylase complex membrane transcription repressor complex Sin3 complex spindle microtubule nucleus nucleoplasm cytosol mitotic spindle Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of production of miRNAs involved in gene silencing by miRNA spindle assembly negative regulation of JNK cascade regulation of fatty acid transport circadian rhythm transcription, DNA-templated regulation of lipid metabolic process chromatin organization negative regulation of transcription, DNA-templated negative regulation of androgen receptor signaling pathway locomotor rhythm rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9611 20185 Ensembl ENSG00000141027 ENSMUSG00000018501 UniProt O75376 Q60974 RefSeq (mRNA) NM_001190438 NM_001190440 NM_006311 NM_001252313 NM_011308 NM_177229 RefSeq (protein) NP_001177367 NP_001177369 NP_006302 n/a Location (UCSC) Chr 17: 16.03 – 16.22 Mb Chr 11: 62.21 – 62.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.^[5][7]

Loss of function of this protein significantly increases the strength and power of mouse muscles.^[8]

Family

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.^[9]

Interactions

Nuclear receptor co-repressor 1 has been shown to interact with:

• Androgen receptor,^{[10][11][12][13]}
• CHD1,^[14]
• Calcitriol receptor^[15][16]
• GPS2,^[17][18][19]
• Glucocorticoid receptor,^[20][21]
• HDAC3,^{[17][18][19][22][23][24][25]}
• HDAC4,^[24][26]
• HDAC7A,^[22]
• HDAC9,^[27]
• HEY2,^[28]
• Histone deacetylase 5,^[17][26]
• MAP3K7IP2,^[29]
• MECP2,^[30]
• Peroxisome proliferator-activated receptor alpha,^[31]
• Peroxisome proliferator-activated receptor gamma
• Promyelocytic leukemia protein,^[32]
• RUNX1T1,^[33][34]
• Retinoic acid receptor alpha,^[31][35]
• Retinoic acid receptor gamma,^[31]
• SAP30,^[25][36]
• TBL1XR1,^[17][18][19]
• TBL1X,^{[17][19][23][37]} and
• ZBTB33.^[18]

Further reading

• Minucci S, Pelicci PG (1999). "Retinoid receptors in health and disease: co-regulators and the chromatin connection". Semin. Cell Dev. Biol. 10 (2): 215–25. doi:10.1006/scdb.1999.0303. PMID 10441075.
• Downes M, Burke LJ, Bailey PJ, Muscat GE (1997). "Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors". Nucleic Acids Res. 24 (22): 4379–86. doi:10.1093/nar/24.22.4379. PMC 146280. PMID 8948627.
• Tagami T, Madison LD, Nagaya T, Jameson JL (1997). "Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone". Mol. Cell. Biol. 17 (5): 2642–8. doi:10.1128/mcb.17.5.2642. PMC 232114. PMID 9111334.
• Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMC 24996. PMID 9405624.
• Burke LJ, Downes M, Laudet V, Muscat GE (1998). "Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha". Mol. Endocrinol. 12 (2): 248–62. doi:10.1210/mend.12.2.0061. PMID 9482666.
• Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
• Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes Dev. 12 (15): 2269–77. doi:10.1101/gad.12.15.2269. PMC 317043. PMID 9694793.
• Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell. 2 (1): 33–42. doi:10.1016/S1097-2765(00)80111-2. PMID 9702189.
• Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. Bibcode:1998PNAS...9510860W. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.
• Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. Bibcode:1999PNAS...96.2639O. doi:10.1073/pnas.96.6.2639. PMC 15821. PMID 10077563.
• Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.
• Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS, Jones AL (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Hum. Mol. Genet. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647. PMID 10441327.
• Nagaya T, Chen KS, Fujieda M, Ohmori S, Richer JK, Horwitz KB, Lupski JR, Seo H (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2". Genomics. 59 (3): 339–41. doi:10.1006/geno.1998.5694. PMID 10444336.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Hu X, Lazar MA (1999). "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors". Nature. 402 (6757): 93–6. Bibcode:1999Natur.402...93H. doi:10.1038/47069. PMID 10573424. S2CID 4380362.
• Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. doi:10.1101/gad.14.1.45. PMC 316335. PMID 10640275.
• Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.
• Masselink H, Bernards R (2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.