NDRG2

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstream-regulated gene 2).^[5][6]

NDRG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XMQ, 2XMR, 2XMS
Identifiers
Aliases	NDRG2, SYLD, NDRG family member 2
External IDs	OMIM: 605272; MGI: 1352498; HomoloGene: 22785; GeneCards: NDRG2; OMA:NDRG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 21,016,763 bp[1] End 21,070,872 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 51,905,271 bp[2] End 51,913,488 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe amygdala right hemisphere of cerebellum nucleus accumbens putamen hypothalamus internal globus pallidus caudate nucleus prefrontal cortex C1 segment Top expressed in muscle of thigh wall of urinary bladder mucosa of urinary bladder transitional epithelium of urinary bladder superior frontal gyrus extensor digitorum longus muscle cerebellar cortex triceps brachii muscle dentate gyrus of hippocampal formation granule cell temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component growth cone nucleus perinuclear region of cytoplasm Golgi apparatus cell projection cytosol extracellular exosome cytoplasm Biological process negative regulation of smooth muscle cell proliferation regulation of vascular endothelial growth factor production negative regulation of cytokine production nervous system development multicellular organism development cell differentiation substantia nigra development Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of platelet-derived growth factor production signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57447 29811 Ensembl ENSG00000165795 ENSMUSG00000004558 UniProt Q9UN36 Q9QYG0 RefSeq (mRNA) NM_001282211 NM_001282212 NM_001282213 NM_001282214 NM_001282215 NM_001282216 NM_016250 NM_201535 NM_201536 NM_201537 NM_201538 NM_201539 NM_201540 NM_201541 NM_001320329 NM_001354559 NM_001354562 NM_001354566 NM_001354567 NM_001354568 NM_001354569 NM_001354570 NM_001354558 NM_001354560 NM_001354561 NM_001354564 NM_001354565 NM_001145959 NM_013864 RefSeq (protein) NP_001269140 NP_001269141 NP_001269142 NP_001269143 NP_001269144 NP_001269145 NP_001307258 NP_057334 NP_963293 NP_963294 NP_963831 NP_963832 NP_963833 NP_963834 NP_963835 NP_001341488 NP_001341491 NP_001341495 NP_001341496 NP_001341497 NP_001341498 NP_001341499 NP_001341487 NP_001341489 NP_001341490 NP_001341493 NP_001341494 NP_001139431 NP_038892 NP_001347193 NP_001347194 NP_001347195 NP_001347196 NP_001347197 NP_001347198 NP_001347199 NP_001347200 NP_001347201 NP_001347202 NP_001347203 NP_001347205 Location (UCSC) Chr 14: 21.02 – 21.07 Mb Chr 14: 51.91 – 51.91 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation^[7]).^[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[6]