NEK6

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.^[5][6]

NEK6
Identifiers
Aliases	NEK6, SID6-1512, NIMA related kinase 6
External IDs	OMIM: 604884; MGI: 1891638; HomoloGene: 49379; GeneCards: NEK6; OMA:NEK6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 124,257,606 bp[1] End 124,353,307 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 24.41 cM Start 38,401,655 bp[2] End 38,484,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium ventricular zone right lobe of liver appendix mucosa of ileum cartilage tissue gallbladder pancreatic ductal cell monocyte Top expressed in ventricular zone epithelium of small intestine jejunum endothelial cell of lymphatic vessel stroma of bone marrow granulocyte neural tube placenta dentate gyrus of hippocampal formation granule cell yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity signal transducer activity metal ion binding kinase activity protein binding kinesin binding ATP binding protein kinase binding magnesium ion binding protein serine/threonine kinase activity transcription corepressor binding ubiquitin protein ligase binding Cellular component cytoplasm nuclear speck spindle pole intracellular membrane-bounded organelle nucleoplasm microtubule organizing center microtubule cytoskeleton nucleus cytosol centrosome Biological process phosphorylation chromosome segregation spindle assembly cell division protein phosphorylation mitotic nuclear membrane disassembly peptidyl-serine phosphorylation regulation of mitotic cell cycle regulation of mitotic metaphase/anaphase transition positive regulation of I-kappaB kinase/NF-kappaB signaling protein autophosphorylation regulation of cellular senescence cell cycle apoptotic process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10783 59126 Ensembl ENSG00000119408 ENSMUSG00000026749 UniProt Q9HC98 Q5TBG4 Q9ES70 RefSeq (mRNA) NM_001145001 NM_001166167 NM_001166168 NM_001166169 NM_001166170 NM_001166171 NM_014397 NM_001159631 NM_021606 RefSeq (protein) NP_001138473 NP_001159639 NP_001159640 NP_001159641 NP_001159642 NP_001159643 NP_055212 NP_001153103 NP_067619 Location (UCSC) Chr 9: 124.26 – 124.35 Mb Chr 2: 38.4 – 38.48 Mb PubMed search [3] [4]
Wikidata
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Function

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.^[6]

It is a protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.^[7]

Interactions

NEK6 has been shown to interact with NEK9.^[8][9][10]