NEUROD2

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.^[5][6]

NEUROD2
Identifiers
Aliases	NEUROD2, NDRF, bHLHa1, neuronal differentiation 2, EIEE72, DEE72
External IDs	OMIM: 601725; MGI: 107755; HomoloGene: 4489; GeneCards: NEUROD2; OMA:NEUROD2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 39,603,536 bp[1] End 39,609,777 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.75 cM Start 98,216,241 bp[2] End 98,220,474 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right hemisphere of cerebellum right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 9 paraflocculus of cerebellum hippocampus proper prefrontal cortex superior frontal gyrus Top expressed in CA3 field primary visual cortex perirhinal cortex entorhinal cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex ventricular zone superior frontal gyrus Region I of hippocampus proper hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity transcription corepressor activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific E-box binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process cellular response to calcium ion regulation of neuron differentiation cell differentiation negative regulation of nucleic acid-templated transcription positive regulation of calcium-mediated signaling associative learning regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity neuron development transcription by RNA polymerase II behavioral fear response transcription, DNA-templated nervous system development positive regulation of synaptic plasticity negative regulation of synapse maturation multicellular organism development positive regulation of synapse maturation protein ubiquitination positive regulation of neuron differentiation cerebellar cortex development regulation of synapse maturation positive regulation of transcription by RNA polymerase II cellular response to electrical stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4761 18013 Ensembl ENSG00000171532 ENSMUSG00000038255 UniProt Q15784 Q62414 RefSeq (mRNA) NM_006160 NM_010895 RefSeq (protein) NP_006151 NP_035025 Location (UCSC) Chr 17: 39.6 – 39.61 Mb Chr 11: 98.22 – 98.22 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.^[6]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.^[7]