NGFRAP1

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.^[5][6][7]

BEX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SA6
Identifiers
Aliases	BEX3, Bex, DXS6984E, HGR74, NADE, NGFRAP1, brain expressed X-linked 3
External IDs	OMIM: 300361; MGI: 1338016; HomoloGene: 7642; GeneCards: BEX3; OMA:BEX3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.2 Start 103,376,395 bp[1] End 103,378,164 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F1|X 57.64 cM Start 135,171,002 bp[2] End 135,172,727 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis pons superior vestibular nucleus middle temporal gyrus Brodmann area 23 ventral tegmental area renal medulla lateral nuclear group of thalamus pars compacta pars reticulata Top expressed in yolk sac somite mandibular prominence maxillary prominence dentate gyrus of hippocampal formation granule cell arcuate nucleus supraoptic nucleus central gray substance of midbrain superior cervical ganglion abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type endopeptidase activator activity involved in apoptotic process nerve growth factor receptor binding death receptor binding protein binding metal ion binding identical protein binding Cellular component cytoplasm nucleus cytosol Biological process multicellular organism development activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27018 12070 Ensembl ENSG00000166681 ENSMUSG00000046432 UniProt Q00994 Q9WTZ9 RefSeq (mRNA) NM_206917 NM_001282674 NM_014380 NM_206915 NM_001110233 NM_001110234 NM_009750 RefSeq (protein) NP_001269603 NP_055195 NP_996798 NP_996800 NP_001103703 NP_001103704 NP_033880 Location (UCSC) Chr X: 103.38 – 103.38 Mb Chr X: 135.17 – 135.17 Mb PubMed search [3] [4]
Wikidata
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Interactions

NGFRAP1 has been shown to interact with YWHAE^[8] and Low affinity nerve growth factor receptor.^[5]