YWHAE

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.^[5]

YWHAE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BR9, 3UAL, 3UBW
Identifiers
Aliases	YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
External IDs	OMIM: 605066; MGI: 894689; HomoloGene: 100743; GeneCards: YWHAE; OMA:YWHAE - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 1,344,275 bp[1] End 1,400,222 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.92 cM Start 75,623,695 bp[2] End 75,656,671 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus ventricular zone primary visual cortex prefrontal cortex ganglionic eminence corpus callosum dorsolateral prefrontal cortex Brodmann area 9 temporal lobe amygdala Top expressed in somite mandibular prominence maxillary prominence Gonadal ridge habenula dorsomedial hypothalamic nucleus optic nerve supraoptic nucleus atrium subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding protein domain specific binding protein-containing complex binding histone deacetylase binding potassium channel regulator activity phosphoprotein binding protein binding MHC class II protein complex binding protein heterodimerization activity enzyme binding phosphoserine residue binding ubiquitin protein ligase binding cadherin binding involved in cell-cell adhesion RNA binding calcium channel regulator activity identical protein binding cadherin binding scaffold protein binding Cellular component cytoplasm cytosol membrane kinesin complex focal adhesion melanosome axon mitochondrion extracellular exosome cytoplasmic vesicle membrane nucleus plasma membrane synapse central region of growth cone glutamatergic synapse Biological process protein targeting negative regulation of protein dephosphorylation intracellular signal transduction substantia nigra development neuron migration negative regulation of peptidyl-serine dephosphorylation hippo signaling positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway G2/M transition of mitotic cell cycle regulation of heart rate by hormone regulation of potassium ion transmembrane transporter activity cerebral cortex development regulation of cellular response to heat regulation of membrane repolarization membrane organization viral process regulation of heart rate by cardiac conduction membrane repolarization during cardiac muscle cell action potential hippocampus development cell-cell adhesion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process MAPK cascade regulation of G2/M transition of mitotic cell cycle protein localization to nucleus cellular response to heat positive regulation of protein export from nucleus regulation of cytosolic calcium ion concentration ciliary basal body-plasma membrane docking regulation of postsynaptic membrane neurotransmitter receptor levels negative regulation of calcium ion transmembrane transporter activity negative regulation of calcium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7531 22627 Ensembl ENSG00000274474 ENSG00000108953 ENSMUSG00000020849 UniProt P62258 P62259 RefSeq (mRNA) NM_006761 NM_009536 RefSeq (protein) NP_006752 NP_033562 Location (UCSC) Chr 17: 1.34 – 1.4 Mb Chr 11: 75.62 – 75.66 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer,^[6] and microdeletions associated with Miller–Dieker syndrome.^[7]

Interactions

YWHAE has been shown to interact with:

• C-Raf,^[8][9]
• CDC25B,^[10][8]
• HDAC4,^[11][12]
• HERG,^[13]
• IRS1^[14] and
• IGF1R,^[14]
• MAP3K3,^[15]
• NDEL1,^[16]
• NGFRAP1,^[17] and
• TGF beta 1.^[18]

See also

• 14-3-3 protein