NHP2L1

NHP2-like protein 1 is a protein that in humans is encoded by the SNU13 gene.^[4][5]

SNU13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E7K, 2JNB, 2OZB, 3SIU, 3SIV, 3JCR
Identifiers
Aliases	SNU13, 15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1, NHP2L1, SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5), small nuclear ribonucleoprotein 13
External IDs	OMIM: 601304; MGI: 893586; HomoloGene: 3672; GeneCards: SNU13; OMA:SNU13 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,673,933 bp[1] End 41,690,504 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell prefrontal cortex Hypothalamus right frontal lobe muscle of thigh right ventricle stromal cell of endometrium left testis right auricle of heart Brodmann area 9 n/a More reference expression data BioGPS n/a
Gene ontology Molecular function U3 snoRNA binding ATPase binding U4 snRNA binding U4atac snRNA binding protein binding snoRNA binding RNA binding box C/D RNA binding Cellular component nucleoplasm spliceosomal complex nucleus small-subunit processome U4/U6 x U5 tri-snRNP complex nucleolus dense fibrillar component cytosolic large ribosomal subunit precatalytic spliceosome box C/D RNP complex U4atac snRNP protein-containing complex U2-type precatalytic spliceosome ribonucleoprotein complex Biological process mRNA processing ribosome biogenesis mRNA splicing, via spliceosome RNA splicing maturation of LSU-rRNA maturation of SSU-rRNA protein biosynthesis rRNA processing single fertilization box C/D snoRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4809 20826 Ensembl ENSG00000100138 ENSMUSG00000063480 UniProt P55769 Q9D0T1 RefSeq (mRNA) NM_001003796 NM_005008 NM_011482 RefSeq (protein) NP_001003796 NP_004999 NP_035612 Location (UCSC) Chr 22: 41.67 – 41.69 Mb n/a PubMed search [2] [3]
Wikidata
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Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.^[5]

Interactions

SNU13 has been shown to interact with RAD17.^[6]