NLGN1

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.^[5][6][7]

NLGN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B3Q
Identifiers
Aliases	NLGN1, NL1, neuroligin 1
External IDs	OMIM: 600568; MGI: 2179435; HomoloGene: 56690; GeneCards: NLGN1; OMA:NLGN1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.31 Start 173,396,284 bp[1] End 174,294,372 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 25,480,379 bp[2] End 26,386,609 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone endothelial cell sural nerve Achilles tendon ganglionic eminence stromal cell of endometrium testicle buccal mucosa cell entorhinal cortex corpus callosum Top expressed in olfactory tubercle lumbar subsegment of spinal cord piriform cortex substantia nigra dentate gyrus anterior amygdaloid area ventromedial nucleus dentate gyrus of hippocampal formation granule cell lateral septal nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein dimerization activity cell adhesion molecule binding scaffold protein binding carboxylic ester hydrolase activity neurexin family protein binding amyloid-beta binding signaling receptor activity Cellular component synapse integral component of membrane NMDA selective glutamate receptor complex Golgi apparatus cell junction dendritic shaft filopodium tip dendritic spine postsynaptic membrane membrane dendrite excitatory synapse external side of plasma membrane cell surface presynapse postsynaptic density plasma membrane integral component of postsynaptic membrane integral component of plasma membrane spanning component of membrane postsynapse glutamatergic synapse asymmetric, glutamatergic, excitatory synapse integral component of postsynaptic specialization membrane Biological process NMDA glutamate receptor clustering positive regulation of ruffle assembly positive regulation of synaptic vesicle exocytosis regulation of AMPA receptor activity rhythmic process positive regulation of synaptic transmission, glutamatergic heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules positive regulation of circadian sleep/wake cycle, wakefulness regulation of respiratory gaseous exchange by nervous system process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules protein heterotetramerization synaptic vesicle transport terminal button organization synapse organization positive regulation of synaptic transmission, GABAergic postsynaptic density protein 95 clustering receptor localization to synapse protein localization to synapse neurexin clustering involved in presynaptic membrane assembly positive regulation of synaptic vesicle endocytosis synaptic vesicle targeting protein homooligomerization positive regulation of protein localization to synapse neuron projection development protein targeting positive regulation of intracellular signal transduction long-term potentiation nervous system development AMPA glutamate receptor clustering neuronal signal transduction synaptic vesicle clustering positive regulation of synaptic vesicle clustering cytoskeletal matrix organization at active zone synapse assembly establishment of protein localization modulation of chemical synaptic transmission positive regulation of filopodium assembly cell adhesion regulation of neuron differentiation neuron cell-cell adhesion positive regulation of dendritic spine development regulation of NMDA receptor activity positive regulation of excitatory postsynaptic potential negative regulation of dendritic spine morphogenesis positive regulation of synapse assembly excitatory synapse assembly positive regulation of presynaptic active zone assembly retrograde trans-synaptic signaling by trans-synaptic protein complex synaptic vesicle endocytosis postsynaptic membrane assembly presynaptic membrane assembly cellular response to calcium ion postsynaptic specialization assembly presynapse assembly regulation of presynapse organization synaptic membrane adhesion neuron projection arborization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22871 192167 Ensembl ENSG00000169760 ENSMUSG00000063887 UniProt Q8N2Q7 Q99K10 RefSeq (mRNA) NM_014932 NM_001365923 NM_001365924 NM_001365925 NM_001365926 NM_001365927 NM_001365928 NM_001365929 NM_001365930 NM_001365931 NM_001365932 NM_001365933 NM_001365934 NM_001365935 NM_001365936 NM_001163387 NM_138666 NM_001357095 NM_001357096 NM_001357097 RefSeq (protein) NP_055747 NP_001352852 NP_001352853 NP_001352854 NP_001352855 NP_001352856 NP_001352857 NP_001352858 NP_001352859 NP_001352860 NP_001352861 NP_001352862 NP_001352863 NP_001352864 NP_001352865 NP_001156859 NP_619607 NP_001344024 NP_001344025 NP_001344026 Location (UCSC) Chr 3: 173.4 – 174.29 Mb Chr 3: 25.48 – 26.39 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.^[7][8]

Interactions

NLGN1 has been shown to interact with NRXN1^[9][10] and DLG4.^[11]

See also

• Neurexins: NRXN1, NRXN2, NRXN3