NME1

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene.^[5] It is thought to be a metastasis suppressor.

NME1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JXV, 1UCN, 2HVD, 2HVE, 3L7U, 4ENO
Identifiers
Aliases	NME1, AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1, NME/NM23 nucleoside diphosphate kinase 1
External IDs	OMIM: 156490; MGI: 97355; HomoloGene: 128514; GeneCards: NME1; OMA:NME1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 51,153,559 bp[1] End 51,162,428 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 93,847,805 bp[2] End 93,859,347 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex hypothalamus Brodmann area 9 superior frontal gyrus islet of Langerhans ganglionic eminence right frontal lobe hippocampus proper primary visual cortex cingulate gyrus Top expressed in right kidney epiblast neural tube proximal tubule embryo embryo ganglionic eminence dentate gyrus of hippocampal formation granule cell morula blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding deoxyribonuclease activity ribosomal small subunit binding GTP binding metal ion binding kinase activity protein binding identical protein binding ATP binding magnesium ion binding nucleoside diphosphate kinase activity RNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding single-stranded DNA binding intermediate filament binding enzyme binding protein kinase binding gamma-tubulin binding Cellular component ruffle membrane extracellular exosome nucleus cytoplasm mitochondrial outer membrane centrosome cytosol intermediate filament membrane perinuclear region of cytoplasm mitochondrion myelin sheath Biological process UTP biosynthetic process regulation of apoptotic process cell differentiation nucleobase-containing small molecule interconversion CTP biosynthetic process endocytosis phosphorylation positive regulation of epithelial cell proliferation nucleotide metabolic process nucleoside diphosphate phosphorylation nervous system development positive regulation of DNA binding GTP biosynthetic process negative regulation of cell population proliferation DNA metabolic process negative regulation of myeloid leukocyte differentiation negative regulation of gene expression positive regulation of neuron projection development response to amine hippocampus development response to testosterone response to cAMP cellular response to glucose stimulus cellular response to fatty acid lactation mammary gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4830 18102 Ensembl ENSG00000239672 ENSMUSG00000037601 UniProt P15531 P15532 RefSeq (mRNA) NM_198175 NM_000269 NM_008704 NM_001378854 RefSeq (protein) NP_000260 NP_937818 NP_032730 NP_001365783 Location (UCSC) Chr 17: 51.15 – 51.16 Mb Chr 11: 93.85 – 93.86 Mb PubMed search [3] [4]
Wikidata
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For the radio station, see NME Radio.

Function

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.^[6]

A bioinformatics study published in 2023 suggested that the NME1 gene might have a prognostic role in neuroblastoma.^[7]

Interactions

NME1 has been shown to interact with:

• Aurora A kinase,^[8]
• CD29^[9]
• NME3,^[10][11]
• Protein SET,^[12]
• RAR-related orphan receptor alpha,^[13]
• RAR-related orphan receptor beta,^[13] and
• TERF1.^[14]

See also

• Nucleoside-diphosphate kinase