NOL1

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene.^[5][6]

NOP2
Identifiers
Aliases	NOP2, NOL1, NOP120, NSUN1, p120, NOP2 nucleolar protein
External IDs	OMIM: 164031; MGI: 107891; HomoloGene: 135865; GeneCards: NOP2; OMA:NOP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,556,863 bp[1] End 6,568,691 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.32 cM Start 125,108,872 bp[2] End 125,121,716 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node appendix spleen left uterine tube gastrocnemius muscle islet of Langerhans right lobe of thyroid gland anterior pituitary tonsil Top expressed in epiblast otic placode otic vesicle morula morula superior surface of tongue gallbladder somite embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity protein binding S-adenosylmethionine-dependent methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity RNA binding Cellular component nucleus nucleolus nucleoplasm Biological process rRNA processing methylation rRNA base methylation maturation of LSU-rRNA positive regulation of cell population proliferation regulation of transcription by RNA polymerase II ribosomal large subunit assembly regulation of signal transduction by p53 class mediator ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4839 110109 Ensembl ENSG00000111641 ENSMUSG00000038279 UniProt P46087 Q922K7 RefSeq (mRNA) NM_001033714 NM_001258308 NM_001258309 NM_001258310 NM_006170 NM_138747 RefSeq (protein) NP_001028886 NP_001245237 NP_001245238 NP_001245239 NP_006161 n/a Location (UCSC) Chr 12: 6.56 – 6.57 Mb Chr 6: 125.11 – 125.12 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.^[7]

Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.^[8] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.^[9]

Interactions

NOL1 has been shown to interact with MCRS1.^[10]