MCRS1

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.^[5][6][7]

MCRS1
Identifiers
Aliases	MCRS1, ICP22BP, INO80Q, MCRS2, MSP58, P78, microspherule protein 1
External IDs	OMIM: 609504; MGI: 1858420; HomoloGene: 4622; GeneCards: MCRS1; OMA:MCRS1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,556,544 bp[1] End 49,568,145 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 99,140,698 bp[2] End 99,149,842 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart granulocyte left ventricle right auricle of heart right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon right frontal lobe body of stomach left testis Top expressed in mesencephalon neural tube ganglionic eminence spermatocyte ventricular zone epiblast spermatid neural layer of retina limb muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(U) RNA binding histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K5 specific) poly(G) binding protein binding histone acetyltransferase activity (H4-K16 specific) telomerase inhibitor activity G-quadruplex RNA binding Cellular component nucleoplasm nucleolus histone acetyltransferase complex nucleus dendrite cytoplasm polysome perikaryon endoplasmic reticulum Ino80 complex MLL1 complex NSL complex Biological process positive regulation of protein localization to nucleolus DNA recombination regulation of transcription, DNA-templated negative regulation of telomerase activity transcription, DNA-templated histone H4-K5 acetylation cellular response to DNA damage stimulus negative regulation of telomere maintenance via telomere lengthening histone H4-K16 acetylation histone H4-K8 acetylation DNA repair protein deubiquitination chromatin organization positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10445 51812 Ensembl ENSG00000187778 ENSMUSG00000037570 UniProt Q96EZ8 Q99L90 RefSeq (mRNA) NM_001012300 NM_001278341 NM_006337 NM_001164156 NM_016766 RefSeq (protein) NP_001012300 NP_001265270 NP_006328 NP_001157628 NP_058046 Location (UCSC) Chr 12: 49.56 – 49.57 Mb Chr 15: 99.14 – 99.15 Mb PubMed search [3] [4]
Wikidata
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Interactions

MCRS1 has been shown to interact with PHC2,^[8] Death associated protein 6,^[9] NOL1,^[6] PINX1^[10] and Telomerase reverse transcriptase.^[10]