NOS1AP

Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.^[3][4][5]

NOS1AP
Identifiers
Aliases	NOS1AP, 6330408P19Rik, CAPON, nitric oxide synthase 1 adaptor protein, NPHS22
External IDs	OMIM: 605551; HomoloGene: 136252; GeneCards: NOS1AP; OMA:NOS1AP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,069,691 bp[1] End 162,370,475 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Region I of hippocampus proper cerebellar vermis frontal pole orbitofrontal cortex prefrontal cortex paraflocculus of cerebellum right hemisphere of cerebellum superior frontal gyrus Brodmann area 46 parietal lobe n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nitric-oxide synthase binding Cellular component L-type voltage-gated calcium channel complex cytosol nuclear membrane inward rectifier potassium channel complex perinuclear region of cytoplasm sarcolemma nucleus mitochondrion caveola Z discdkac T-tubule sarcoplasmic reticulum membrane glutamatergic synapse Biological process positive regulation of peptidyl-cysteine S-nitrosylation regulation of cardiac muscle cell action potential positive regulation of nitric oxide biosynthetic process regulation of nitric-oxide synthase activity positive regulation of delayed rectifier potassium channel activity positive regulation of gene expression positive regulation of nitric oxide mediated signal transduction positive regulation of nitric-oxide synthase activity regulation of high voltage-gated calcium channel activity positive regulation of potassium ion transmembrane transport regulation of heart rate by chemical signal positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization regulation of nitric oxide biosynthetic process regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of ventricular cardiac muscle cell membrane repolarization postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9722 n/a Ensembl ENSG00000198929 n/a UniProt O75052 n/a RefSeq (mRNA) NM_014697 NM_001126060 NM_001164757 n/a RefSeq (protein) NP_001119532 NP_001158229 NP_055512 n/a Location (UCSC) Chr 1: 162.07 – 162.37 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.^[5] NOS1AP polymorphisms has been associated with the QT interval length.^[6]

Interactions

NOS1AP has been shown to interact with:

• LRP1,^[7]
• LRP2,^[7]
• NOS1,^[4]
• RASD1,^[8]
• SYN1^[9]