NPTXR

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.^[5][6]

NPTXR
Identifiers
Aliases	NPTXR, NPR, neuronal pentraxin receptor
External IDs	OMIM: 609474; MGI: 1920590; HomoloGene: 8620; GeneCards: NPTXR; OMA:NPTXR - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,818,452 bp[1] End 38,844,028 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.85 cM Start 79,670,552 bp[2] End 79,688,967 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole Region I of hippocampus proper right frontal lobe cingulate gyrus anterior cingulate cortex dorsolateral prefrontal cortex Amygdala Brodmann area 9 orbitofrontal cortex Top expressed in piriform cortex subiculum dentate gyrus of hippocampal formation granule cell primary visual cortex anterior amygdaloid area superior frontal gyrus habenula primary motor cortex cingulate gyrus medial dorsal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding Cellular component membrane integral component of membrane plasma membrane cytoplasmic side of plasma membrane filopodium dendrite growth cone soma glutamatergic synapse Biological process neuron projection development regulation of postsynaptic neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23467 73340 Ensembl ENSG00000221890 ENSMUSG00000022421 UniProt O95502 Q99J85 RefSeq (mRNA) NM_058178 NM_014293 NM_030689 RefSeq (protein) NP_055108 n/a Location (UCSC) Chr 22: 38.82 – 38.84 Mb Chr 15: 79.67 – 79.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.^[6]

See also

• NPTX2, Neuronal pentraxin II