NSL1

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.^[5]

NSL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NF9
Identifiers
Aliases	NSL1, C1orf48, MIS14, DC8, MIS12 kinetochore complex component, NSL1 component of MIS12 kinetochore complex
External IDs	OMIM: 609174; MGI: 2685830; HomoloGene: 22898; GeneCards: NSL1; OMA:NSL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 212,726,153 bp[1] End 212,791,782 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H6 Start 190,795,209 bp[2] End 190,818,671 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte optic nerve germinal epithelium Epithelium of choroid plexus hair follicle tibia inferior ganglion of vagus nerve trabecular bone kidney tubule parietal pleura Top expressed in hand yolk sac epiblast primitive streak ventricular zone spermatocyte embryo tail of embryo cumulus cell thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component MIS12/MIND type complex chromosome, centromeric region nucleus kinetochore chromosome nucleoplasm nuclear speck cytosol Biological process cell division cell cycle chromosome segregation mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25936 381318 Ensembl ENSG00000117697 ENSMUSG00000062510 UniProt Q96IY1 Q8K305 RefSeq (mRNA) NM_015471 NM_001042549 NM_001297736 NM_001297737 NM_001297739 NM_198654 RefSeq (protein) NP_001036014 NP_001284665 NP_001284666 NP_001284668 NP_056286 n/a Location (UCSC) Chr 1: 212.73 – 212.79 Mb Chr 1: 190.8 – 190.82 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

NSL1 has been shown to interact with MIS12^[6] and DSN1.^[6]