DSN1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.^[5][6]

DSN1
Identifiers
Aliases	DSN1, C20orf172, KNL3, MIS13, dJ469A13.2, hKNL-3, DSN1 homolog, MIS12 kinetochore complex component, DSN1 component of MIS12 kinetochore complex
External IDs	OMIM: 609175; MGI: 1914184; HomoloGene: 49806; GeneCards: DSN1; OMA:DSN1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 36,751,791 bp[1] End 36,773,818 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,837,185 bp[2] End 156,849,074 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone right testis secondary oocyte left testis ganglionic eminence testicle rectum right adrenal cortex mucosa of transverse colon Top expressed in zygote secondary oocyte spermatocyte primary oocyte spermatid genital tubercle yolk sac ventricular zone tail of embryo morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component MIS12/MIND type complex chromosome, centromeric region nucleus kinetochore chromosome extracellular region cytosol azurophil granule lumen nuclear MIS12/MIND complex spindle pole fibrillar center nucleolus nuclear body Biological process chromosome segregation cell division cell cycle neutrophil degranulation mitotic sister chromatid segregation attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79980 66934 Ensembl ENSG00000149636 ENSMUSG00000027635 UniProt Q9H410 Q9CYC5 RefSeq (mRNA) NM_001145315 NM_001145316 NM_001145317 NM_001145318 NM_024918 NM_025853 RefSeq (protein) NP_001138787 NP_001138788 NP_001138789 NP_001138790 NP_079194 NP_080129 Location (UCSC) Chr 20: 36.75 – 36.77 Mb Chr 2: 156.84 – 156.85 Mb PubMed search [3] [4]
Wikidata
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Function

DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis.^[6][7]

Interactions

DSN1 has been shown to interact with NSL1^[8] and MIS12.^[6][9]