POU2F1

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.^[5][6]

POU2F1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CQT, 1E3O, 1GT0, 1HF0, 1O4X, 1OCT, 1POG
Identifiers
Aliases	POU2F1, OCT1, OTF1, oct-1B, POU class 2 homeobox 1, Oct1Z
External IDs	OMIM: 164175; MGI: 101898; HomoloGene: 37658; GeneCards: POU2F1; OMA:POU2F1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 167,220,876 bp[1] End 167,427,345 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 73.21 cM Start 165,692,723 bp[2] End 165,830,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell secondary oocyte sural nerve gonad testicle Achilles tendon cerebellar vermis Skeletal muscle tissue of rectus abdominis tendon of biceps brachii epithelium of colon Top expressed in Rostral migratory stream zygote tail of embryo genital tubercle secondary oocyte primitive streak primary oocyte renal corpuscle ciliary body embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding protein binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II general transcription initiation factor activity DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component endoplasmic reticulum nucleus intracellular membrane-bounded organelle nucleoplasm RNA polymerase II transcription regulator complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated snRNA transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5451 18986 Ensembl ENSG00000143190 ENSMUSG00000026565 UniProt P14859 P25425 RefSeq (mRNA) NM_001198783 NM_001198786 NM_002697 NM_001365848 NM_001365849 NM_011137 NM_198932 NM_198933 NM_198934 NM_001368808 RefSeq (protein) NP_001185712 NP_001185715 NP_002688 NP_001352777 NP_001352778 NP_035267 NP_945150 NP_945151 NP_945152 NP_001355737 Location (UCSC) Chr 1: 167.22 – 167.43 Mb Chr 1: 165.69 – 165.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POU2F1 has been shown to interact with:

• EPRS,^[7]
• Glucocorticoid receptor,^[8][9][10]
• Glyceraldehyde 3-phosphate dehydrogenase,^[11]
• Host cell factor C1,^[12][13]
• Ku80,^[14][15]
• MNAT1^[16]
• NPAT,^[11]
• Nuclear receptor co-repressor 2,^[17]
• POU2AF1,^[18][19][20]
• RELA,^[21]
• Retinoid X receptor alpha,^[8][22]
• SNAPC4,^[18][23]
• Sp1 transcription factor,^[24][25] and
• TATA binding protein.^[26]

See also

• Octamer transcription factor