Retinoid X receptor alpha

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.^[5]

RXRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1LBD, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5, 4RFW, 4RMC, 4RMD, 4RME, 4ZO1, 5EC9, 4ZSH
Identifiers
Aliases	RXRA, NR2B1, Retinoid X receptor alpha, RXR-alpha, RXRalpha
External IDs	OMIM: 180245; MGI: 98214; HomoloGene: 2220; GeneCards: RXRA; OMA:RXRA - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 134,317,098 bp[1] End 134,440,585 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.38 cM Start 27,566,452 bp[2] End 27,652,969 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of hip gingival epithelium pancreatic ductal cell gastrocnemius muscle right lobe of liver vastus lateralis muscle Skeletal muscle tissue of rectus abdominis blood Skeletal muscle tissue of biceps brachii trabecular bone Top expressed in lip muscle of thigh medulla of thymus left lobe of liver transitional epithelium of urinary bladder Ileal epithelium genital tubercle medullary collecting duct ankle molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity vitamin D response element binding transcription coactivator activity transcription factor binding retinoic acid-responsive element binding metal ion binding steroid hormone receptor activity nuclear receptor activity protein binding protein heterodimerization activity enzyme binding chromatin DNA binding vitamin D receptor binding retinoic acid binding double-stranded DNA binding zinc ion binding nuclear receptor binding peptide binding DNA binding domain binding LBD domain binding DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity Cellular component receptor complex nucleoplasm RNA polymerase II transcription regulator complex nucleus protein-containing complex Biological process steroid hormone mediated signaling pathway regulation of branching involved in prostate gland morphogenesis regulation of transcription, DNA-templated placenta development peroxisome proliferator activated receptor signaling pathway regulation of transcription by RNA polymerase II cholesterol metabolic process in utero embryonic development negative regulation of transcription by RNA polymerase II cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development transcription, DNA-templated positive regulation of transcription, DNA-templated ventricular cardiac muscle tissue morphogenesis heart development retinoic acid receptor signaling pathway maternal placenta development modulation by virus of host process vitamin metabolic process bile acid and bile salt transport ventricular cardiac muscle cell differentiation camera-type eye development viral process protein homotetramerization transcription initiation from RNA polymerase II promoter embryo implantation positive regulation of translational initiation by iron positive regulation of transcription by RNA polymerase II positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus response to retinoic acid regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6256 20181 Ensembl ENSG00000186350 ENSMUSG00000015846 UniProt P19793 P28700 RefSeq (mRNA) NM_002957 NM_001291920 NM_001291921 NM_001290481 NM_001290482 NM_011305 RefSeq (protein) NP_001278849 NP_001278850 NP_002948 NP_001277410 NP_001277411 NP_035435 Location (UCSC) Chr 9: 134.32 – 134.44 Mb Chr 2: 27.57 – 27.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors.^[6] In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the cytochrome P450 system genes.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Vitamin D Synthesis Pathway (view / edit)]]

Vitamin D Synthesis Pathway (view / edit)

1. The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

Interactions

Retinoid X receptor alpha has been shown to interact with:

• BCL3,^[8]
• BRD8,^[9]
• CLOCK,^[10]
• FXR^[11]
• IGFBP3,^[12]
• ITGB3BP,^[13]
• LXR-β,^[11]
• MyoD,^[14]
• NCOA6,^{[15][16][17][18]}
• NFKBIB,^[19]
• NPAS2,^[10]
• NRIP1,^[20][21]
• NR4A1,^[22]
• NCOA2,^[23]
• NCOA3,^[24]
• POU2F1,^[25][26]
• PPARGC1A,^[27]
• PPAR-γ,^[28][29][30]
• RNF8,^[31]
• RAR-α,^[32][33]
• SHP,^[34][35]
• TADA3L,^[36]
• TBP,^[37]
• TRIM24,^[38][39]
• TR-β,^[40][41] and
• VDR.^[23][42]

See also

• Retinoid X receptor