PABPC4

Polyadenylate-binding protein 4 (PABPC4) is a protein that in humans is encoded by the PABPC4 gene.^[5][6]

PABPC4
Identifiers
Aliases	PABPC4, APP-1, APP1, PABP4, iPABP, poly(A) binding protein cytoplasmic 4
External IDs	OMIM: 603407; MGI: 2385206; HomoloGene: 37855; GeneCards: PABPC4; OMA:PABPC4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 39,560,709 bp[1] End 39,576,790 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 123,156,144 bp[2] End 123,192,718 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gastrocnemius muscle muscle of thigh secondary oocyte glutes skeletal muscle tissue vastus lateralis muscle body of tongue triceps brachii muscle left ovary Top expressed in bone marrow epiblast muscle of thigh skeletal muscle tissue tail of embryo quadriceps femoris muscle morula yolk sac genital tubercle primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(C) RNA binding protein binding poly(A) binding nucleic acid binding poly(U) RNA binding RNA binding mRNA binding mRNA 3'-UTR binding Cellular component cytoplasmic stress granule nucleus cytoplasm cytosol ribonucleoprotein complex Biological process RNA processing RNA catabolic process blood coagulation protein biosynthesis regulation of mRNA stability myeloid cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8761 230721 Ensembl ENSG00000090621 ENSMUSG00000011257 UniProt Q13310 n/a RefSeq (mRNA) NM_003819 NM_001135653 NM_001135654 NM_130881 NM_148917 NM_001356377 RefSeq (protein) NP_001129125 NP_001129126 NP_003810 n/a Location (UCSC) Chr 1: 39.56 – 39.58 Mb Chr 4: 123.16 – 123.19 Mb PubMed search [3] [4]
Wikidata
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Function

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.^[6]

Interactions

PABPC4 has been shown to interact with PHLDA1.^[7]