ADCYAP1R1

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC₁, is a protein that in humans is encoded by the ADCYAP1R1 gene.^[5] This receptor binds pituitary adenylate cyclase activating peptide.^[6][7]

ADCYAP1R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JOD
Identifiers
Aliases	ADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI, ADCYAP receptor type I
External IDs	OMIM: 102981; MGI: 108449; HomoloGene: 870; GeneCards: ADCYAP1R1; OMA:ADCYAP1R1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 31,052,308 bp[1] End 31,111,479 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B3 Start 55,428,963 bp[2] End 55,478,436 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence nucleus accumbens caudate nucleus amygdala entorhinal cortex right frontal lobe internal globus pallidus cingulate gyrus anterior cingulate cortex right hemisphere of cerebellum Top expressed in paraventricular nucleus of hypothalamus dentate gyrus of hippocampal formation granule cell arcuate nucleus lateral septal nucleus Rostral migratory stream dorsomedial hypothalamic nucleus ventral tegmental area substantia nigra lateral hypothalamus ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity adenylate cyclase binding neuropeptide binding vasoactive intestinal polypeptide receptor activity signal transducer activity protein binding transmembrane signaling receptor activity signaling receptor activity G protein-coupled peptide receptor activity peptide hormone binding Cellular component cytoplasm integral component of membrane endosome rough endoplasmic reticulum membrane bicellular tight junction receptor complex plasma membrane integral component of plasma membrane cell surface caveola neuron projection intracellular membrane-bounded organelle Biological process cell differentiation multicellular organismal response to stress response to estradiol positive regulation of calcium ion transport into cytosol positive regulation of inositol phosphate biosynthetic process negative regulation of cell death activation of phospholipase C activity multicellular organism development cell surface receptor signaling pathway development of primary female sexual characteristics spermatogenesis response to ethanol cAMP-mediated signaling signal transduction positive regulation of small GTPase mediated signal transduction G protein-coupled receptor signaling pathway positive regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117 11517 Ensembl ENSG00000078549 ENSMUSG00000029778 UniProt P41586 P70205 RefSeq (mRNA) NM_001118 NM_001199635 NM_001199636 NM_001199637 NM_001025372 NM_007407 RefSeq (protein) NP_001109 NP_001186564 NP_001186565 NP_001186566 NP_001020543 NP_031433 Location (UCSC) Chr 7: 31.05 – 31.11 Mb Chr 6: 55.43 – 55.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

PAC₁ is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family.^[8] This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.^[5] PAC₁ is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.^[9][10][11] It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).^[12]