PCBP1

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.^[5]

PCBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WVN, 1ZTG, 3VKE
Identifiers
Aliases	PCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
External IDs	OMIM: 601209; MGI: 1345635; HomoloGene: 68506; GeneCards: PCBP1; OMA:PCBP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 70,087,477 bp[1] End 70,089,203 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 86,501,474 bp[2] End 86,503,303 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gastrocnemius muscle muscle of thigh granulocyte right adrenal gland popliteal artery tibial arteries monocyte right adrenal cortex left adrenal gland Top expressed in primitive streak abdominal wall hair follicle migratory enteric neural crest cell medullary collecting duct renal corpuscle endothelial cell of lymphatic vessel mandibular prominence dermis vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding mRNA binding RNA binding nucleic acid binding single-stranded DNA binding sequence-specific single stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cadherin binding Cellular component cytoplasm extracellular exosome membrane nucleus nucleoplasm cytosol nuclear speck cytoplasmic ribonucleoprotein granule Biological process mRNA splicing, via spliceosome viral RNA genome replication positive regulation of transcription by RNA polymerase II RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5093 23983 Ensembl ENSG00000169564 ENSMUSG00000051695 UniProt Q15365 P60335 RefSeq (mRNA) NM_006196 NM_011865 RefSeq (protein) NP_006187 NP_035995 Location (UCSC) Chr 2: 70.09 – 70.09 Mb Chr 6: 86.5 – 86.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.^[6]