PDE7A

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.^[5][6][7] Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

PDE7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKL, 3G3N, 4PM0, 4Y2B
Identifiers
Aliases	PDE7A, HCP1, PDE7, phosphodiesterase 7A
External IDs	OMIM: 171885; MGI: 1202402; HomoloGene: 1956; GeneCards: PDE7A; OMA:PDE7A - orthologs
EC number	3.1.4.53
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.1 Start 65,714,334 bp[1] End 65,842,322 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A2|3 5.36 cM Start 19,277,272 bp[2] End 19,365,486 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte thymus Skeletal muscle tissue of rectus abdominis apex of heart muscle of thigh lymph node gastrocnemius muscle deltoid muscle appendix right auricle of heart Top expressed in left lung lobe spermatocyte Rostral migratory stream conjunctival fornix left colon ganglionic eminence primitive streak spermatid muscle of thigh mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity metal ion binding phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity Cellular component cytosol cytoplasm Biological process cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5150 18583 Ensembl ENSG00000205268 ENSMUSG00000069094 UniProt Q13946 P70453 RefSeq (mRNA) NM_001242318 NM_002603 NM_002604 NM_001122759 NM_008802 RefSeq (protein) NP_001229247 NP_002594 NP_001116231 NP_032828 Location (UCSC) Chr 8: 65.71 – 65.84 Mb Chr 3: 19.28 – 19.37 Mb PubMed search [3] [4]
Wikidata
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